2. PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. mTOR Endogenous Metabolite
  4. L-Leucine-15N

L-Leucine-15N is the 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1][2].

For research use only. We do not sell to patients.

L-Leucine-<sup>15</sup>N Chemical Structure

L-Leucine-15N Chemical Structure

CAS No. : 59935-31-8

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Leucine-15N:

L-Leucine-15N Related Antibodies

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Description

L-Leucine-15N is the 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Leucine-15N Related Antibodies
Molecular Weight

132.17

Formula

C6H1315NO2
CAS No.
Unlabeled CAS

61-90-5
Appearance

Solid

Color

White to off-white

SMILES

CC(C)C[C@H]([15NH2])C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (75.66 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5660 mL 37.8301 mL 75.6601 mL
5 mM 1.5132 mL 7.5660 mL 15.1320 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.5660 mL 37.8301 mL 75.6601 mL 189.1503 mL
5 mM 1.5132 mL 7.5660 mL 15.1320 mL 37.8301 mL
10 mM 0.7566 mL 3.7830 mL 7.5660 mL 18.9150 mL
15 mM 0.5044 mL 2.5220 mL 5.0440 mL 12.6100 mL
20 mM 0.3783 mL 1.8915 mL 3.7830 mL 9.4575 mL
25 mM 0.3026 mL 1.5132 mL 3.0264 mL 7.5660 mL
30 mM 0.2522 mL 1.2610 mL 2.5220 mL 6.3050 mL
40 mM 0.1892 mL 0.9458 mL 1.8915 mL 4.7288 mL
50 mM 0.1513 mL 0.7566 mL 1.5132 mL 3.7830 mL
60 mM 0.1261 mL 0.6305 mL 1.2610 mL 3.1525 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Leucine-15N Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Leucine-15N59935-31-8mTOREndogenous MetaboliteMammalian target of RapamycinInhibitorinhibitorinhibit

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