1. PI3K/Akt/mTOR Metabolic Enzyme/Protease
  2. mTOR Endogenous Metabolite
  3. L-Leucine-d10

L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

For research use only. We do not sell to patients.

L-Leucine-d<sub>10</sub> Chemical Structure

L-Leucine-d10 Chemical Structure

CAS No. : 106972-44-5

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5 mg USD 100 In-stock
10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

141.23

Formula

C6H3D10NO2

CAS No.
Unlabeled CAS

61-90-5

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[C@@](N)([2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (118.03 mM; Need ultrasonic)

PBS (pH 7.2) : ≥ 1 mg/mL (7.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.0806 mL 35.4032 mL 70.8065 mL
5 mM 1.4161 mL 7.0806 mL 14.1613 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / H2O 1 mM 7.0806 mL 35.4032 mL 70.8065 mL 177.0162 mL
5 mM 1.4161 mL 7.0806 mL 14.1613 mL 35.4032 mL
H2O 10 mM 0.7081 mL 3.5403 mL 7.0806 mL 17.7016 mL
15 mM 0.4720 mL 2.3602 mL 4.7204 mL 11.8011 mL
20 mM 0.3540 mL 1.7702 mL 3.5403 mL 8.8508 mL
25 mM 0.2832 mL 1.4161 mL 2.8323 mL 7.0806 mL
30 mM 0.2360 mL 1.1801 mL 2.3602 mL 5.9005 mL
40 mM 0.1770 mL 0.8851 mL 1.7702 mL 4.4254 mL
50 mM 0.1416 mL 0.7081 mL 1.4161 mL 3.5403 mL
60 mM 0.1180 mL 0.5901 mL 1.1801 mL 2.9503 mL
80 mM 0.0885 mL 0.4425 mL 0.8851 mL 2.2127 mL
100 mM 0.0708 mL 0.3540 mL 0.7081 mL 1.7702 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Leucine-d10
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