L-Leucine-d₁₀

Name: L-Leucine-d 10
Brand: MedChemExpress
SKU: HY-N0486S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0486S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

For research use only. We do not sell to patients.

L-Leucine-d<sub>10</sub> Chemical Structure

L-Leucine-d₁₀ Chemical Structure

CAS No. : 106972-44-5

Size	Price	Stock	Quantity
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Leucine-d₁₀:

L-Leucine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

141.23

Formula

C₆H₃D₁₀NO₂

CAS No.

106972-44-5

Unlabeled CAS

61-90-5

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[C@@](N)([2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 16.67 mg/mL (118.03 mM; Need ultrasonic)

PBS (pH 7.2) : ≥ 1 mg/mL (7.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.0806 mL	35.4032 mL	70.8065 mL
5 mM	1.4161 mL	7.0806 mL	14.1613 mL
10 mM	0.7081 mL	3.5403 mL	7.0806 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [Content Brief]

[3]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [Content Brief]

[4]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

PBS (pH 7.2) / H₂O	1 mM	7.0806 mL	35.4032 mL	70.8065 mL	177.0162 mL
PBS (pH 7.2) / H₂O	5 mM	1.4161 mL	7.0806 mL	14.1613 mL	35.4032 mL
H₂O	10 mM	0.7081 mL	3.5403 mL	7.0806 mL	17.7016 mL
	15 mM	0.4720 mL	2.3602 mL	4.7204 mL	11.8011 mL
	20 mM	0.3540 mL	1.7702 mL	3.5403 mL	8.8508 mL
	25 mM	0.2832 mL	1.4161 mL	2.8323 mL	7.0806 mL
	30 mM	0.2360 mL	1.1801 mL	2.3602 mL	5.9005 mL
	40 mM	0.1770 mL	0.8851 mL	1.7702 mL	4.4254 mL
	50 mM	0.1416 mL	0.7081 mL	1.4161 mL	3.5403 mL
	60 mM	0.1180 mL	0.5901 mL	1.1801 mL	2.9503 mL
	80 mM	0.0885 mL	0.4425 mL	0.8851 mL	2.2127 mL
	100 mM	0.0708 mL	0.3540 mL	0.7081 mL	1.7702 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.