L-Lysine-d₈ hydrochloride

Cat. No.: HY-N0470S4 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

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L-Lysine-d₈ (hydrochloride) is the deuterium labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

For research use only. We do not sell to patients.

L-Lysine-d<sub>8</sub> hydrochloride Chemical Structure

L-Lysine-d₈ hydrochloride Chemical Structure

CAS No. : 344298-93-7

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of L-Lysine-d₈ hydrochloride:

L-Lysine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

190.70

Formula

C₆H₇D₈ClN₂O₂

CAS No.

344298-93-7

Unlabeled CAS

657-27-2

Appearance

Solid

Color

White to off-white

SMILES

NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[C@H](N)C(O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (524.38 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2438 mL	26.2192 mL	52.4384 mL
5 mM	1.0488 mL	5.2438 mL	10.4877 mL
10 mM	0.5244 mL	2.6219 mL	5.2438 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (250 KB) HNMR (258 KB) RP-HPLC (324 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]

[3]. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009. [Content Brief]

[4]. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.2438 mL	26.2192 mL	52.4384 mL	131.0960 mL
	5 mM	1.0488 mL	5.2438 mL	10.4877 mL	26.2192 mL
	10 mM	0.5244 mL	2.6219 mL	5.2438 mL	13.1096 mL
	15 mM	0.3496 mL	1.7479 mL	3.4959 mL	8.7397 mL
	20 mM	0.2622 mL	1.3110 mL	2.6219 mL	6.5548 mL
	25 mM	0.2098 mL	1.0488 mL	2.0975 mL	5.2438 mL
	30 mM	0.1748 mL	0.8740 mL	1.7479 mL	4.3699 mL
	40 mM	0.1311 mL	0.6555 mL	1.3110 mL	3.2774 mL
	50 mM	0.1049 mL	0.5244 mL	1.0488 mL	2.6219 mL
	60 mM	0.0874 mL	0.4370 mL	0.8740 mL	2.1849 mL
	80 mM	0.0655 mL	0.3277 mL	0.6555 mL	1.6387 mL
	100 mM	0.0524 mL	0.2622 mL	0.5244 mL	1.3110 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.