L-Methionine-d₈

Cat. No.: HY-N0326S8 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Methionine-d₈ is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

For research use only. We do not sell to patients.

L-Methionine-d<sub>8</sub> Chemical Structure

L-Methionine-d₈ Chemical Structure

CAS No. : 2483831-58-7

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of L-Methionine-d₈:

L-Methionine In-stock

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Biological Activity
Purity & Documentation
References
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Description

L-Methionine-d₈ is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

157.26

Formula

C₅H₃D₈NO₂S

CAS No.

2483831-58-7

Unlabeled CAS

63-68-3

Appearance

Solid

Color

White to off-white

SMILES

OC([C@](N)([2H])C([2H])([2H])C([2H])([2H])SC([2H])([2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 10 mg/mL (63.59 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.3589 mL	31.7945 mL	63.5890 mL
5 mM	1.2718 mL	6.3589 mL	12.7178 mL
10 mM	0.6359 mL	3.1794 mL	6.3589 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.3589 mL	31.7945 mL	63.5890 mL	158.9724 mL
	5 mM	1.2718 mL	6.3589 mL	12.7178 mL	31.7945 mL
	10 mM	0.6359 mL	3.1794 mL	6.3589 mL	15.8972 mL
	15 mM	0.4239 mL	2.1196 mL	4.2393 mL	10.5982 mL
	20 mM	0.3179 mL	1.5897 mL	3.1794 mL	7.9486 mL
	25 mM	0.2544 mL	1.2718 mL	2.5436 mL	6.3589 mL
	30 mM	0.2120 mL	1.0598 mL	2.1196 mL	5.2991 mL
	40 mM	0.1590 mL	0.7949 mL	1.5897 mL	3.9743 mL
	50 mM	0.1272 mL	0.6359 mL	1.2718 mL	3.1794 mL
	60 mM	0.1060 mL	0.5299 mL	1.0598 mL	2.6495 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.