2. Anti-infection
  3. Bacterial
  4. L-NBDNJ

L-NBDNJ, a glycomimetic, is an antivirulence agent. L-NBDNJ interferes with the expression of proteins regulating cytoskeleton assembly and organization of the host cell. L-NBDNJ has anti-inflammatory and anti-infective effects in models of cystic fibrosis (CF) lung disease infection.

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L-NBDNJ Chemical Structure

L-NBDNJ Chemical Structure

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L-NBDNJ Related Antibodies

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Description

L-NBDNJ, a glycomimetic, is an antivirulence agent. L-NBDNJ interferes with the expression of proteins regulating cytoskeleton assembly and organization of the host cell. L-NBDNJ has anti-inflammatory and anti-infective effects in models of cystic fibrosis (CF) lung disease infection[1].

In Vitro

L-NBDNJ, a glycomimetic, is an antivirulence agent. L-NBDNJ interferes with the expression of proteins regulating cytoskeleton assembly and organization of the host cell. L-NBDNJ has to interfere with the metabolic paths involved in cytoskeleton assembly and organization of the host cell, downregulate the main virulence factors of P. aeruginosa involved in the host response, and affect pathogen adhesion to human cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-NBDNJ Related Antibodies
In Vivo

L-NBDNJ (10-100 mg/kg; oral gavage; daily; for 6 days) shows anti-inflammatory and anti-infective effects in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6NCr mice infected by P. aeruginosa MDR-RP73[1]
Dosage: 10 and 100 mg/kg
Administration: Oral gavage; daily; for 6 days (starting 24 h before infection)
Result: A significant and substantial decrease in bacteria recovered from the airways of mice observed[1].
Showed a moderate reduction of some chemokines and cytokines activated by infection[1].
Molecular Weight

219.28

Formula

C10H21NO4
SMILES

CCCCN1[C@@H](CO)[C@H](O)[C@@H](O)[C@H](O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-NBDNJ Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-NBDNJBacterialanti-inflammatoryanti-infective effectscystic fibrosisantivirulence agentInhibitorinhibitorinhibit

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