L-Palmitoylcarnitine-d₃ hydrochloride

Name: L-Palmitoylcarnitine-d 3 hydrochloride
Brand: MedChemExpress
SKU: HY-113147AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-113147AS Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Palmitoylcarnitine-d₃ (hydrochloride) is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].

For research use only. We do not sell to patients.

L-Palmitoylcarnitine-d<sub>3</sub> hydrochloride Chemical Structure

L-Palmitoylcarnitine-d₃ hydrochloride Chemical Structure

CAS No. : 1334532-26-1

Size	Price	Stock	Quantity
1 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Palmitoylcarnitine-d₃ hydrochloride:

L-Palmitoylcarnitine chloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

439.09

Formula

C₂₃H₄₃D₃ClNO₄

CAS No.

1334532-26-1

Unlabeled CAS

18877-64-0

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(O[C@H](CC(O)=O)C[N+](C)(C)C([2H])([2H])[2H])=O.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (56.94 mM; ultrasonic and warming and heat to 60°C)

Ethanol : ≥ 20 mg/mL (45.55 mM)

DMF : ≥ 20 mg/mL (45.55 mM)

Ethanol : ≥ 20 mg/mL (45.55 mM)

DMSO : ≥ 10 mg/mL (22.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2774 mL	11.3872 mL	22.7744 mL
5 mM	0.4555 mL	2.2774 mL	4.5549 mL
10 mM	0.2277 mL	1.1387 mL	2.2774 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (242 KB) HNMR (1195 KB) RP-HPLC (1301 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / Ethanol / DMF / DMF / Ethanol / H₂O	1 mM	2.2774 mL	11.3872 mL	22.7744 mL	56.9359 mL
	5 mM	0.4555 mL	2.2774 mL	4.5549 mL	11.3872 mL
	10 mM	0.2277 mL	1.1387 mL	2.2774 mL	5.6936 mL
	15 mM	0.1518 mL	0.7591 mL	1.5183 mL	3.7957 mL
	20 mM	0.1139 mL	0.5694 mL	1.1387 mL	2.8468 mL
Ethanol / DMF / DMF / Ethanol / H₂O	25 mM	0.0911 mL	0.4555 mL	0.9110 mL	2.2774 mL
	30 mM	0.0759 mL	0.3796 mL	0.7591 mL	1.8979 mL
	40 mM	0.0569 mL	0.2847 mL	0.5694 mL	1.4234 mL
H₂O	50 mM	0.0455 mL	0.2277 mL	0.4555 mL	1.1387 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.