2. Peptides
  3. Reagents for Peptide Synthesis
  4. Amino acids and Derivatives
  5. L-Selenocystine

L-Selenocystine is a diselenide-bridged amino acid. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types.

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L-Selenocystine Chemical Structure

L-Selenocystine Chemical Structure

CAS No. : 29621-88-3

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100 mg USD 68 In-stock
250 mg USD 132 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of L-Selenocystine:

L-Selenocystine Related Antibodies

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Description

L-Selenocystine is a diselenide-bridged amino acid. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
3.6 μM
Compound: 1
Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
CNE-2 IC50
5.6 μM
Compound: 1
Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
HL-60 IC50
34.5 μM
Compound: 1
Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
SW-620 IC50
7.3 μM
Compound: 1
Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
Molecular Weight

334.09

Formula

C6H12N2O4Se2
CAS No.
Appearance

Solid

Color

Light yellow to brown

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5.88 mg/mL (17.60 mM; ultrasonic and warming and adjust pH to 1 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9932 mL 14.9660 mL 29.9321 mL
5 mM 0.5986 mL 2.9932 mL 5.9864 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

SDS (788 KB)

COA (243 KB) HNMR (130 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9932 mL 14.9660 mL 29.9321 mL 74.8301 mL
5 mM 0.5986 mL 2.9932 mL 5.9864 mL 14.9660 mL
10 mM 0.2993 mL 1.4966 mL 2.9932 mL 7.4830 mL
15 mM 0.1995 mL 0.9977 mL 1.9955 mL 4.9887 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Selenocystine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Selenocystine29621-88-3Othersanti-oxidantpro-oxidantamino acid ERcancerHeLaInhibitorinhibitorinhibit

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