L-Selenocystine

Name: L-Selenocystine
Brand: MedChemExpress
SKU: HY-129960
Rating: 4.5 (1 reviews)

Cat. No.: HY-129960 Purity: ≥97.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

L-Selenocystine Chemical Structure

CAS No. : 29621-88-3

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Selenocystine:

Selenocystine Get quote
L-Selenocystine-⁷⁷Se₂ Get quote

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	3.6 μM Compound: 1	Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
CNE-2	IC₅₀	5.6 μM Compound: 1	Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
HL-60	IC₅₀	34.5 μM Compound: 1	Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
SW-620	IC₅₀	7.3 μM Compound: 1	Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]

In Vitro

L-Selenocystine (8-32 μM; 24 h) can inhibit the proliferation of HepG2 cells (IC₅₀: 5.444 μM) and induce the production of ROS and apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HepG2
Concentration:	8, 16, 32 μM
Incubation Time:	24 h
Result:	Significantly inhibited HepG2 cell growth with increasing concentration.

Western Blot Analysis^[1]

Cell Line:	HepG2
Concentration:	8, 16, 32 μM
Incubation Time:	/
Result:	Inhibited the levels of Bid, Bax, Cleaved Caspase-9, Cleaved Caspase-3 and Cleaved PARP. Reduced the levels of Bcl2.

Molecular Weight

334.09

Formula

C₆H₁₂N₂O₄Se₂

CAS No.

29621-88-3

Appearance

Solid

Color

Light yellow to brown

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 5.88 mg/mL (17.60 mM; ultrasonic and warming and adjust pH to 1 with HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9932 mL	14.9660 mL	29.9321 mL
5 mM	0.5986 mL	2.9932 mL	5.9864 mL
10 mM	0.2993 mL	1.4966 mL	2.9932 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

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Data Sheet (271 KB) SDS (788 KB)

COA (244 KB) HNMR (130 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. CHEN H, et al. L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways. Biocell, 2022, 46(10).

[2]. Hsu WL, et al. Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis. Cell Death Dis. 2022 Dec 20;13(12):1060. [Content Brief]

[3]. Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74.Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74. [Content Brief]

[4]. Roy J, et al. Optically active selenium-containing amino acids. The synthesis of L-selenocystine and L-selenolanthionine. J Org Chem. 1970 Feb;35(2):510-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9932 mL	14.9660 mL	29.9321 mL	74.8301 mL
	5 mM	0.5986 mL	2.9932 mL	5.9864 mL	14.9660 mL
	10 mM	0.2993 mL	1.4966 mL	2.9932 mL	7.4830 mL
	15 mM	0.1995 mL	0.9977 mL	1.9955 mL	4.9887 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-Selenocystine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-Selenocystine

Customer Review

Other Forms of L-Selenocystine:

L-Selenocystine Related Antibodies

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Biological Activity

Purity & Documentation

References

Customer Review

L-Selenocystine Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

L-Selenocystine Related Classifications

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SAFETY DATA SHEET (SDS)

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