2. Membrane Transporter/Ion Channel
  3. EAAT
  4. L-threo-3-Hydroxyaspartic acid

L-threo-3-Hydroxyaspartic acid 

Cat. No.: HY-100801 Purity: 98.80%
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L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines.

For research use only. We do not sell to patients.

L-threo-3-Hydroxyaspartic acid Chemical Structure

L-threo-3-Hydroxyaspartic acid Chemical Structure

CAS No. : 7298-99-9

Size Price Stock Quantity
1 mg USD 164 In-stock
5 mg USD 409 In-stock
10 mg USD 655 Get quote
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of L-threo-3-Hydroxyaspartic acid:

L-threo-3-Hydroxyaspartic acid Related Antibodies

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EAAT1 EAAT2 EAAT3 EAAT4 EAAT5

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Description

L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].

IC50 & Target

Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2)[1]
Molecular Weight

149.10

Formula

C4H7NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H]([C@H](O)C(O)=O)C(O)=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M NaOH : 14.91 mg/mL (100.00 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7069 mL 33.5345 mL 67.0691 mL
5 mM 1.3414 mL 6.7069 mL 13.4138 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M NaOH 1 mM 6.7069 mL 33.5345 mL 67.0691 mL 167.6727 mL
5 mM 1.3414 mL 6.7069 mL 13.4138 mL 33.5345 mL
10 mM 0.6707 mL 3.3535 mL 6.7069 mL 16.7673 mL
15 mM 0.4471 mL 2.2356 mL 4.4713 mL 11.1782 mL
20 mM 0.3353 mL 1.6767 mL 3.3535 mL 8.3836 mL
25 mM 0.2683 mL 1.3414 mL 2.6828 mL 6.7069 mL
30 mM 0.2236 mL 1.1178 mL 2.2356 mL 5.5891 mL
40 mM 0.1677 mL 0.8384 mL 1.6767 mL 4.1918 mL
50 mM 0.1341 mL 0.6707 mL 1.3414 mL 3.3535 mL
60 mM 0.1118 mL 0.5589 mL 1.1178 mL 2.7945 mL
80 mM 0.0838 mL 0.4192 mL 0.8384 mL 2.0959 mL
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L-threo-3-Hydroxyaspartic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-threo-3-Hydroxyaspartic acid7298-99-9EAATExcitatory amino acid transporter Glutamate transporter;Inhibitorinhibitorinhibit

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