2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. L759633

L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production.

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L759633 Chemical Structure

L759633 Chemical Structure

CAS No. : 174627-50-0

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Based on 1 publication(s) in Google Scholar

L759633 Related Antibodies

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Description

L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production[1][2].

IC50 & Target[1]

CB2

6.4 nM (Ki)

CB1

1043 nM (Ki)

In Vitro

L759633 (0.1-1000 nM) inhibits Forskolin-stimulated cyclic AMP production in CB2-transfected cells, with an EC50 of 8.1 nM[1].
L759633 inhibits Forskolin-stimulated cyclic AMP production by 48% at the concentration of 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L759633 Related Antibodies
Molecular Weight

384.59

Formula

C26H40O2
CAS No.
SMILES

COC1=C2[C@@]3([H])[C@](CC=C(C)C3)([H])C(C)(C)OC2=CC(C(C)(C)CCCCCC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L759633 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L759633174627-50-0L 759633L-759633Cannabinoid ReceptorCB2CB1ForskolincAMPInhibitorinhibitorinhibit

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L759633
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HY-110040
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