2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. L759633

L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production.

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L759633 Chemical Structure

L759633 Chemical Structure

CAS No. : 174627-50-0

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Solvent
1 mg (26 mM * 100 μL in Methyl acetate) In-stock
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Based on 1 publication(s) in Google Scholar

L759633 Related Antibodies

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Description

L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production[1][2].

IC50 & Target[1]

CB2

6.4 nM (Ki)

CB1

1043 nM (Ki)

In Vitro

L759633 (0.1-1000 nM) inhibits Forskolin-stimulated cyclic AMP production in CB2-transfected cells, with an EC50 of 8.1 nM[1].
L759633 inhibits Forskolin-stimulated cyclic AMP production by 48% at the concentration of 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L759633 Related Antibodies
Molecular Weight

384.59

Formula

C26H40O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

COC1=C2[C@@]3([H])[C@](CC=C(C)C3)([H])C(C)(C)OC2=CC(C(C)(C)CCCCCC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References
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L759633 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L759633174627-50-0L 759633L-759633Cannabinoid ReceptorCB2CB1ForskolincAMPInhibitorinhibitorinhibit

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L759633
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HY-110040
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