LAS191859

Cat. No.: HY-123596: FAQs
Data Sheet Handling Instructions

Molarity Calculator

LAS191859 is an orally active, potent and selective CRTh2 antagonist with an IC₅₀ of 9.58 nM against human CRTh2. LAS191859 can be used for the research of chronic asthma.

For research use only. We do not sell to patients.

LAS191859 Chemical Structure

CAS No. : 1420071-13-1

Size	Price	Stock	Quantity
1 mg	USD 665	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

Synthetic products have potential research and development risk.

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Prostaglandin Receptor Isoform Specific Products:

View All Isoforms

DP EP FP IP TXA₂/TP TXB₂

Biological Activity
Purity & Documentation
References
Customer Review

Description

LAS191859 is an orally active, potent and selective CRTh2 antagonist with an IC₅₀ of 9.58 nM against human CRTh2. LAS191859 can be used for the research of chronic asthma^[1].

IC₅₀ & Target

IC50: 7.6 nM (guinea pig CRTh2), 9.58 nM (human CRTh2), 14 nM (rat CRTh2), 15.5 nM (mouse CRTh2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	10 nM Compound: 14	Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measured after 2 hrs by liquid scintillation counting analysis Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measured after 2 hrs by liquid scintillation counting analysis	[PMID: 25437505]

Molecular Weight

459.46

Formula

C₂₄H₂₄F₃N₃O₃

CAS No.

1420071-13-1

SMILES

CCN(CC1=CC(C(F)(F)F)=CC=C1N2C=C(C3=C2N=C(C=C3)C)CC(O)=O)C(C4CC4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Calbet M, et al. Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy. Pharmacol Res. 2016 Sep;111:208-216. [Content Brief]

LAS191859 Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAS1918591420071-13-1LAS 191859LAS-191859Prostaglandin ReceptorCHO-K1systemic eosinophiliaguinea pigInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks