2. Metabolic Enzyme/Protease
  3. NAMPT
  4. LB-60-OF61

LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.

For research use only. We do not sell to patients.

LB-60-OF61 Chemical Structure

LB-60-OF61 Chemical Structure

CAS No. : 794461-93-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 544 In-stock
Solution
10 mM * 1 mL in DMSO USD 544 In-stock
Solid
1 mg USD 200 In-stock
5 mg USD 500 In-stock
10 mg USD 820 In-stock
25 mg USD 1600 In-stock
50 mg USD 2700 In-stock
100 mg USD 4200 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of LB-60-OF61:

LB-60-OF61 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines[1].

IC50 & Target

NAMPT[1]
In Vitro

LB-60-OF61 is potent against HCT116 cells with an IC50 around 30 nM as measured in a 384 well format[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LB-60-OF61 Related Antibodies
Molecular Weight

494.59

Formula

C29H30N6O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC=C(OCC2=CC3=C(N=C(C#N)N=C3)N2CCC4CCCCC4)C=C1)NCC5=CC=CN=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (404.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0219 mL 10.1094 mL 20.2188 mL
5 mM 0.4044 mL 2.0219 mL 4.0438 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0219 mL 10.1094 mL 20.2188 mL 50.5469 mL
5 mM 0.4044 mL 2.0219 mL 4.0438 mL 10.1094 mL
10 mM 0.2022 mL 1.0109 mL 2.0219 mL 5.0547 mL
15 mM 0.1348 mL 0.6740 mL 1.3479 mL 3.3698 mL
20 mM 0.1011 mL 0.5055 mL 1.0109 mL 2.5273 mL
25 mM 0.0809 mL 0.4044 mL 0.8088 mL 2.0219 mL
30 mM 0.0674 mL 0.3370 mL 0.6740 mL 1.6849 mL
40 mM 0.0505 mL 0.2527 mL 0.5055 mL 1.2637 mL
50 mM 0.0404 mL 0.2022 mL 0.4044 mL 1.0109 mL
60 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8424 mL
80 mM 0.0253 mL 0.1264 mL 0.2527 mL 0.6318 mL
100 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.5055 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

LB-60-OF61 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LB-60-OF61794461-93-1NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorHCT116cellscytotoxicMYCoverexpressingselectivityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LB-60-OF61
Cat. No.:
HY-101280
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.