LBG30300

Cat. No.: HY-162117: FAQs
Data Sheet Handling Instructions

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LBG30300 is a subtype-selective mGlu₂ receptor agonist EC₅₀ 0.6 nM. LBG30300 is blood-brain barrier permeable.

For research use only. We do not sell to patients.

LBG30300 Chemical Structure

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
Customer Review

Description

LBG30300 is a subtype-selective mGlu₂ receptor agonist EC₅₀ 0.6 nM. LBG30300 is blood-brain barrier permeable^[1].

IC₅₀ & Target

mGlu2 Receptor

0.6 nM (EC₅₀)

mGluR3

0.373 μM (EC₅₀)

mGlu₄

0.11 μM (EC₅₀)

mGlu₆

0.28 μM (EC₅₀)

mGlu8 Receptor

0.097 μM (EC₅₀)

Molecular Weight

217.18

Formula

C₈H₁₁NO₆

SMILES

O=C([C@@H]1[C@@H]([C@H](N)C(O)=O)[C@@H]1CC(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu N, et al. Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist. J Med Chem. 2024 Jan 3. [Content Brief]

LBG30300 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LBG30300LBG 30300LBG-30300mGluRMetabotropic glutamate receptorsMetabotropic glutamate (Glu)Excitatory neurotransmission,Inhibitorinhibitorinhibit

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