2. Cell Cycle/DNA Damage Immunology/Inflammation
  3. NEKs Interleukin Related
  4. LC-04-045

LC-04-045 is a NEK7 (NIMA-related kinase 7) molecular glue degrader (MGD). LC-04-045 demonstrates potent activity of NEK7 degradation with a DC50 (half-maximal degradation) of 7 nM and a Dmax (maximum degradation) of 90% in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome. LC-04-045 degrades NEK7 mediated by the ubiquitin-proteasome system (UPS) and relies on the glycine 57 (G57)-containing degron motif in NEK7. LC-04-045 effectively inhibits secretion of IL-1β and IL-18 with IC50s of 33.03 nM and 32.99 nM, respectively. LC-04-045 is potential for inflammatory diseases research.

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LC-04-045 Chemical Structure

LC-04-045 Chemical Structure

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LC-04-045 Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

LC-04-045 is a NEK7 (NIMA-related kinase 7) molecular glue degrader (MGD). LC-04-045 demonstrates potent activity of NEK7 degradation with a DC50 (half-maximal degradation) of 7 nM and a Dmax (maximum degradation) of 90% in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome. LC-04-045 degrades NEK7 mediated by the ubiquitin-proteasome system (UPS) and relies on the glycine 57 (G57)-containing degron motif in NEK7. LC-04-045 effectively inhibits secretion of IL-1β and IL-18 with IC50s of 33.03 nM and 32.99 nM, respectively. LC-04-045 is potential for inflammatory diseases research[1].

IC50 & Target[1]

NEK7

7 nM (DC50)

IL-1β

33.03 nM (IC50)

IL-8

32.99 nM (IC50)

Molecular Weight

566.05

Formula

C32H28ClN5O3
SMILES

O=C([C@@H](N(CC1=C2C=CC(C3=CN=C4CN(CC5=CC=CC=C5C6=CC=CC=C6Cl)CCN43)=C1)C2=O)CC7)NC7=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LC-04-045 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC-04-045NEKsInterleukin RelatedNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesILprotein degradationMGD targetscytokinesMOLT-4 cellsInhibitorinhibitorinhibit

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HY-172162
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