2. Peptides
  3. Peptide and Derivatives
  4. Inhibitors and Substrates
  5. LCKLSL

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles.

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LCKLSL Chemical Structure

LCKLSL Chemical Structure

CAS No. : 533902-29-3

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Other Forms of LCKLSL:

LCKLSL Related Antibodies

Top Publications Citing Use of Products

    LCKLSL purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Mar;159:114173.  [Abstract]

    LCKLSL (5 μM) intervention significantly inhibits ANXA2 protein expression levels when compare to the alcohol group, in activated HSC-T6 cells.

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    Description

    LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].

    IC50 & Target

    Annexin A2 (AnxA2)[1]
    In Vitro

    In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    LCKLSL Related Antibodies
    In Vivo

    Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    675.88

    Formula

    C30H57N7O8S
    CAS No.
    Sequence

    Leu-Cys-Lys-Leu-Ser-Leu
    Sequence Shortening

    LCKLSL
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    LCKLSL Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LCKLSL533902-29-3OthersAnti-proteolyticneovascularizationplasminAnxA2anti-angiogenictPAN-terminalhexapeptideInhibitorinhibitorinhibit

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