LE 28 

LE 28 is a selective and activity-dependent legumain probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases^[1].

LE 28 (0-5 μM, 1 h) can label legumain in RAW cell lysates by lysis and fluorescent SDS-PAGE method^[1].
LE 28 (1 μM 5 h) colocalizes well with Lysotracker in in RAW cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LE 28 (2 mg/kg, i.v.) produces specific signal in the kidney of mice^[1].
LE 28 (2 mg/kg, i.v.) signal is detected around the periphery of the tumors at 30 min, with maximal contrast between tumor and normal tissue achieved after 7 hours in HCT-116 xenograft tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1909.22

C₁₀₂H₁₁₁N₁₀O₂₁S₃⁺

1416080-97-1

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Edgington LE, et al. Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc. 2013 Jan 9;135(1):174-82.  [Content Brief]