2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Lei-Dab7 TFA

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

For research use only. We do not sell to patients.

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Lei-Dab7 TFA Chemical Structure

Lei-Dab7 TFA Chemical Structure

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100 μg USD 430 In-stock
500 μg USD 1200 In-stock
1 mg USD 1850 In-stock
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Based on 1 publication(s) in Google Scholar

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Lei-Dab7 TFA Related Antibodies

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Description

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

Molecular Weight

3392.06 (free base)

Formula

C141H236N46O39S6.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Ala-Phe-Cys-Asn-Leu-Arg-{Dab}-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)
Sequence Shortening

AFCNLR{Dab}CQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation
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Lei-Dab7 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lei-Dab7Potassium ChannelKcsAInhibitorinhibitorinhibit

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