Lercanidipine-d₃ hydrochloride

Cat. No.: HY-B0612DS1 Purity: 98.14%: FAQs
Data Sheet SDS COA Handling Instructions

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Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

For research use only. We do not sell to patients.

Lercanidipine-d<sub>3</sub> hydrochloride Chemical Structure

Lercanidipine-d₃ hydrochloride Chemical Structure

CAS No. : 1189954-18-4

Size	Price	Stock	Quantity
1 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of Lercanidipine-d₃ hydrochloride:

Lercanidipine Get quote
(R)-Lercanidipine hydrochloride Get quote
(R)-Lercanidipine-d₃ hydrochloride Get quote
(S)-Lercanidipine-d₃ hydrochloride Get quote

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•Related Small Molecules:

•Related Proteins:

View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

651.21

Formula

C₃₆H₃₉D₃ClN₃O₆

CAS No.

1189954-18-4

Unlabeled CAS

132866-11-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

C(OC(CN(CCC(C1=CC=CC=C1)C2=CC=CC=C2)C([2H])([2H])[2H])(C)C)(=O)C=3C(C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (30.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5356 mL	7.6780 mL	15.3560 mL
5 mM	0.3071 mL	1.5356 mL	3.0712 mL
10 mM	0.1536 mL	0.7678 mL	1.5356 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.14%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) HNMR (94 KB) RP-HPLC (78 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70. [Content Brief]

[3]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7. [Content Brief]

[4]. Grassi G, et, al. Lercanidipine in the Management of Hypertension: An Update. J Pharmacol Pharmacother. Oct-Dec 2017;8(4):155-165. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5356 mL	7.6780 mL	15.3560 mL	38.3901 mL
	5 mM	0.3071 mL	1.5356 mL	3.0712 mL	7.6780 mL
	10 mM	0.1536 mL	0.7678 mL	1.5356 mL	3.8390 mL
	15 mM	0.1024 mL	0.5119 mL	1.0237 mL	2.5593 mL
	20 mM	0.0768 mL	0.3839 mL	0.7678 mL	1.9195 mL
	25 mM	0.0614 mL	0.3071 mL	0.6142 mL	1.5356 mL
	30 mM	0.0512 mL	0.2559 mL	0.5119 mL	1.2797 mL