1. Metabolic Enzyme/Protease
  2. Aminoacyl-tRNA Synthetase
  3. LeuRS-IN-2

LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota.

For research use only. We do not sell to patients.

LeuRS-IN-2 Chemical Structure

LeuRS-IN-2 Chemical Structure

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Description

LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota[1].

In Vitro

The potent activity LeuRS-IN-2 (9 μM, 7 days) translates in very good in cellulo efficacy with an EC50 value of 90 nM in the Wolbachia infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

419.12

Formula

C19H24BBrN2O3

SMILES

CN(CCCOC1=CC=C(Br)C2=C1B(O)O[C@@H]2CN)CC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
LeuRS-IN-2
Cat. No.:
HY-159103
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