LeuRS-IN-2

Cat. No.: HY-159103: FAQs
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LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC₅₀ value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota.

For research use only. We do not sell to patients.

LeuRS-IN-2 Chemical Structure

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Description	LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC₅₀ value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota^[1].
In Vitro	The potent activity LeuRS-IN-2 (9 μM, 7 days) translates in very good in cellulo efficacy with an EC₅₀ value of 90 nM in the Wolbachia infection model^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. LeuRS-IN-2 Related Antibodies
Molecular Weight	419.12
Formula	C₁₉H₂₄BBrN₂O₃
SMILES	CN(CCCOC1=CC=C(Br)C2=C1B(O)O[C@@H]2CN)CC3=CC=CC=C3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Hoffmann G, et al. Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host[J]. Sci Adv. 2024 Jul 12;10(28):eado1453. [Content Brief]

LeuRS-IN-2 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LeuRS-IN-2Aminoacyl-tRNA SynthetasetRNA Synthetase, aaRSWolbachiaLeuRSadenosine-based adductsprotein synthesisantimicrobialsInhibitorinhibitorinhibit

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LeuRS-IN-2

LeuRS-IN-2 Related Antibodies

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