LFS-1107

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LFS-1107 is a reversible CRM1 inhibitor (K_d: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research.

For research use only. We do not sell to patients.

LFS-1107 Chemical Structure

CAS No. : 1799330-91-8

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Biological Activity
Purity & Documentation
References
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Description

LFS-1107 is a reversible CRM1 inhibitor (K_d: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research^[1].

IC₅₀ & Target

COX-2

In Vitro

LFS-1107 (4-9 μM, 72 h) can selectively eliminate ENKTL cells while sparing normal human PBMC with good safety profile in PBMC cell lines^[1].
LFS-1107 (0.15-500 μM, 24 h) barely exhibits any effects in human platelets^[1].
LFS-1107 (50-200 nM, 3 h) can lead to nuclear accumulation IκBα in 293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SNK6, HANK-1
Concentration:	0-800 nM
Incubation Time:	72 h
Result:	Achieved IC₅₀ value of 26 nM in SNK6 cell line and 36 nM in HANK-1 cell line.

Western Blot Analysis^[1]

Cell Line:	SNK6
Concentration:	62.5 nM, 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time:	3 h
Result:	Suppressed the expression of CRM1 in a dose-dependent manner. Downregulated the expression of proinflammatory and proliferative proteins p65, COX-2, c-Myc, and Survivin in a dose dependent manner.

Immunofluorescence^[1]

Cell Line:	293T cells
Concentration:	50 nM, 100 nM, 200 nM
Incubation Time:	3 h
Result:	Could lead to nuclear accumulation of IκBα in a dose dependent manner.

In Vivo

LFS-1107 (10 mg/kg, Intraperitoneal injection,once a week) can ameliorate the symptoms of ENKTL in SNK6 cell xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SNK6 cell xenograft mouse model^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.), once a week
Result:	Extended mouse survival and Eliminated tumor cells.

Molecular Weight

305.38

Formula

C₁₂H₁₁N₅OS₂

CAS No.

1799330-91-8

SMILES

O=S(C1=NN=NN1C2=CC=CC=C2)/C=C/CCN=C=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. He Liu, et al. Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma eLife 12:e80625.

LFS-1107 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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