Lifirafenib maleate (Synonyms: BGB-283 maleate)

Cat. No.: HY-18957B: FAQs
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Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC₅₀ values of 23 and 29 nM for recombinant BRaf^V600E and EGFR, respectively.

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Lifirafenib maleate Chemical Structure

CAS No. : 1854985-74-2

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Other In-stock Forms of Lifirafenib maleate:

Lifirafenib

Other Forms of Lifirafenib maleate:

1 Publications Citing Use of MCE Lifirafenib maleate

•J Med Virol. 2022 Oct 17. [Abstract]

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•Related Proteins:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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BRaf c-Raf Raf

Biological Activity
Purity & Documentation
References
Customer Review

Description	Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC₅₀ values of 23 and 29 nM for recombinant BRaf^V600E and EGFR, respectively^[1].
IC₅₀ & Target	IC50: 23 nM (recombinant BRafV600E ), 29 nM (EGFR)^[1]
Molecular Weight	652.53
Formula	C₂₅H₁₇F₃N₄O₃.3/2C₄H₄O₄
CAS No.	1854985-74-2
SMILES	O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.O=C(/C=C/C(O)=O)O.[1.5]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Tang Z, et al. BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14(10):2187-97. [Content Brief]

Lifirafenib maleate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lifirafenib1854985-74-2BGB-283BGB283BGB 283EGFRRafEpidermal growth factor receptorErbB-1HER1Raf kinasesrecombinant BRafInhibitorinhibitorinhibit

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