Lifitegrast-d₄ (Synonyms: SAR 1118-d₄; SHP-606-d₄)

Cat. No.: HY-19344S: FAQs
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Lifitegrast-d₄ (SAR 1118-d₄) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease.

For research use only. We do not sell to patients.

Lifitegrast-d<sub>4</sub> Chemical Structure

Lifitegrast-d₄ Chemical Structure

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Description	Lifitegrast-d₄ (SAR 1118-d₄) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease^[1]^[2].
Molecular Weight	619.51
Formula	C₂₉H₂₀D₄Cl₂N₂O₇S
Unlabeled CAS	1025967-78-5
SMILES	O=C(O)[C@H](CC1=CC=CC(S(=O)(C)=O)=C1)NC(C2=C(Cl)C3=C(CN(C(C4=CC=C5C=COC5=C4)=O)C([2H])([2H])C3([2H])[2H])C=C2Cl)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Lifitegrast-d₄ Related Classifications

Inflammation/Immunology

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lifitegrast-d₄SAR 1118-d₄ SHP-606-d₄Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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Lifitegrast-d4 (Synonyms: SAR 1118-d4; SHP-606-d4)

Other Forms of Lifitegrast-d4:

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