2. Cell Cycle/DNA Damage
  3. LIM Kinase (LIMK)
  4. LIMK1 inhibitor BMS-4

LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells.

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LIMK1 inhibitor BMS-4 Chemical Structure

LIMK1 inhibitor BMS-4 Chemical Structure

CAS No. : 905298-84-2

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Based on 1 publication(s) in Google Scholar

LIMK1 inhibitor BMS-4 Related Antibodies

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Description

LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].

IC50 & Target[2]

LIMK1

7.25 (pIC50)

LIMK2

6.87 (pIC50)

In Vitro

LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) inhibits LIMKs in vitro without affecting A549 cell survival or proliferation[1].
LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) inhibits phosphorylation of the LIMK substrate cofilin in A549 human lung cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LIMK1 inhibitor BMS-4 Related Antibodies
Molecular Weight

461.54

Formula

C23H23N7O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC)NC1=NC=C(C2=CC(C3=C(C)C=C(C=C3C)OC)=NC(C4=NC=CN=C4)=N2)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References
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LIMK1 inhibitor BMS-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIMK1 inhibitor BMS-4905298-84-2LIM Kinase (LIMK)LIMKsInhibitorinhibitorinhibit

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