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  4. LIN28-IN-1

LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM).

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LIN28-IN-1 Chemical Structure

LIN28-IN-1 Chemical Structure

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LIN28-IN-1 Related Antibodies

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Description

LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM)[1].

IC50 & Target

IC50: 5.4 μM (LIN28-let-7)[1]
Molecular Weight

714.77

Formula

C40H38N6O7
SMILES

OC(C1=CC=C(N2C(C(C=C([N+]([O-])=O)C(N3CCN(C(OCC4=CC=CC=C4)=O)CC3)=C5)=C5OC67CCN(CC8=CC=CC=C8)CC7)=C6C=N2)C=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LIN28-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIN28-IN-1OthersLIN28 inhibitoranticancerlet-7 miRNAprotein-RNA interactionsmall molecule modulatorInhibitorinhibitorinhibit

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