Liothyronine hydrochloride  (Synonyms: Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride)

Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively^[1][2][3].

TRβ1^[1][2]

Liothyronine (T3, 100 nM) hydrochloride stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed^[1]. Liothyronine hydrochloride binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine hydrochloride promotes growth, induces differentiation and regualtes metabolic effects^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

687.43

C₁₅H₁₃ClI₃NO₄

6138-47-2

O=C([C@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(C(I)=C2)O)N)O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.  [Content Brief]

  [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.  [Content Brief]

  [3]. Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34.  [Content Brief]