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  4. Lipopolysaccharides, from Akkermansia muciniphila

Lipopolysaccharides, from Akkermansia muciniphila  (Synonyms: LPS, from Akkermansia muciniphila)

Cat. No.: HY-D1056I
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Lipopolysaccharides, from Akkermansia muciniphila (LPS, from Akkermansia muciniphila) are lipopolysaccharide endotoxins derived from Akkermansia muciniphila and are TLR-4 activators. Unlike typical LPS, Lipopolysaccharides, from Akkermansia muciniphila are R-type LPS or lipooligosaccharides (LOS), lacking the O-antigen domain and consisting only of a core oligosaccharide and a lipid A. Lipopolysaccharides, from Akkermansia muciniphila can activate TLR4 and TLR2, and may inhibit the TLR4/NF-κB pathway, thereby alleviating LPS-induced acute kidney injury.

For research use only. We do not sell to patients.

Lipopolysaccharides, from Akkermansia muciniphila Chemical Structure

Lipopolysaccharides, from Akkermansia muciniphila Chemical Structure

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Based on 1 publication(s) in Google Scholar

Lipopolysaccharides, from Akkermansia muciniphila Related Antibodies

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Description

Lipopolysaccharides, from Akkermansia muciniphila (LPS, from Akkermansia muciniphila) are lipopolysaccharide endotoxins derived from Akkermansia muciniphila and are TLR-4 activators. Unlike typical LPS, Lipopolysaccharides, from Akkermansia muciniphila are R-type LPS or lipooligosaccharides (LOS), lacking the O-antigen domain and consisting only of a core oligosaccharide and a lipid A. Lipopolysaccharides, from Akkermansia muciniphila can activate TLR4 and TLR2, and may inhibit the TLR4/NF-κB pathway, thereby alleviating LPS-induced acute kidney injury[1][2].

In Vitro

Note:
To maintain the integrity of LPS, it is recommended to store LPS solution in silanized containers. This is because LPS can adhere to plastics and certain types of glass, particularly at concentrations below 0.1 mg/mL. If the LPS concentration exceeds 1 mg/mL, this adsorption effect is relatively minimal. If using glass containers, ensure that the solution is thoroughly mixed for at least 30 minutes before use to redissolve any LPS that may have adsorbed to the tube walls.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lipopolysaccharides, from Akkermansia muciniphila Related Antibodies
In Vivo

Lipopolysaccharides, from Akkermansia muciniphila (300 μg/kg, 230 μL; ip; single dose) can induce high IL-10 gene expression and activate the gene expression of TLR2 and TLR4 in the mouse liver, with TLR2 showing a higher expression level than TLR4 (100 times higher)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SMILES

[Lipopolysaccharides, from Akkermansia muciniphila]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lipopolysaccharides, from Akkermansia muciniphila Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from Akkermansia muciniphilaLPS, from Akkermansia muciniphilaBiochemical Assay ReagentsInhibitorinhibitorinhibit

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