Blogs | MedChemExpress

Enavatuzumab (PDL192) is a Humanized IgG1 Monoclonal Antibody Targeting TWEAK

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TWEAK with potent antitumor activity.
Salviolone is a Natural Diterpenoid Derivative That Can Against Melanoma Cells

Salviolone is a natural diterpene identified from Salvia miltiorrhiza roots with an anti-melanoma activity.
ABT-510 is an Anti-Angiogenic Thrombospondin Peptide

ABT-510, a peptide analog of thrombospondin-1 (TSP-1), can block angiogenesis in vitro and in vivo, and slow tumor growth.
Indoximod, An Immunometabolic Adjuvant, is an IDO Pathway Inhibitor

Indoximod, an immunometabolic adjuvant, is an orally active IDO pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR.
Lomeguatrib is a O6-Methylguanine-DNA Methyltransferase (MGMT) Inhibitor

Lomeguatrib is a highly potent MGMT inactivator, improves the therapeutic effect of alkylating agents in a number of tumour models.
β-Lapachone, a Naturally Occurring O-naphthoquinone, is a Topoisomerase I Inhibitor

β-Lapachone, a topoisomerase I inhibitor, induces apoptosis by inhibiting cell cycle progression. β-Lapachone has anti-inflammatory effect.
Apitolisib is an Orally Active Class I PI3K and mTORC1/2 Inhibitor

Apitolisib is a potent Class I PI3 kinase and mTORC1/2 inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/β/δ/γ, respectively.
CBL0137 is an Histone Chaperone FACT Inhibitor

CBL0137 is an inhibitor of the histone chaperone, FACT. CBL0137 activates p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 µM, respectively.
CX-5461 is an Orally Active rRNA Synthesis Inhibitor

CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis with potent antitumor activity.
Elesclomol (STA-4783) is an Oxidative Stress Inducer and Induces Apoptosis

Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer.

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Blogs (43)