Blogs | MedChemExpress

DK419 Is a Potent Inhibitor of Wnt/β-Catenin Signaling for Colorectal Cancer Treatment

DK419 is an orally active Wnt/β-catenin inhibitor, with an IC50 of 0.19 μM. DK419 reduces Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin expression.
TAS4464, a Highly Potent and Selective Inhibitor of NEDD8 Activating Enzyme, Shows Antitumor Activity

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM. TAS4464 shows antitumor activity.
AMG 487, a Selective CXCR3 Antagonist, Has Potential to Treat Metastatic Cancer

AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). AMG 487 has potential to treat metastatic cancer.
GW7604, the Metabolite of GW5638, is a Selective Estrogen Receptor Downregulator (SERD)

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist
NG25, a Dual Inhibitor of TAK1 and MAP4K2, Enhances Doxorubicin-mediated Apoptosis in Breast Cancer

NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. NG25 enhances Dox-mediated apoptosis in breast cancer.
PTC299 is an Oral Active and Dual Inhibitor of DHODH and VEGF

PTC299 is a dual and orally active DHODH and VEGF inhibitor, has broad and potent activity against hematological cancer cells.
MA242 is a Dual Inhibitor of MDM2 and NFAT1

MA242 is a dual inhibitor of murine double minute 2 (MDM2) and nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy.
Alisertib is an Oral Active and Selective Aurora A Kinase Inhibitor

Alisertib (MLN 8237) is an oral active and selective Aurora A kinase inhibitor with an IC50 of 1.2 nM. To treat hematologic malignancies and solid tumors.
TH34, an HDAC6/8/10 Inhibitor, Induces Caspase-Dependent Programmed Cell Death

TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3.
S18-000003 is a Selective and Orally Active RORγt Inhibitor

2019-06-22

S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt). S18-000003 ameliorates psoriasis-like lesions in vivo. S18-000003 can be used for the research of skin inflammatory diseases.

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Blogs (32)