Blogs | MedChemExpress

BPK-29, a NR0B1 Ligand, Disrupts Protein Interactions for NR0B1-WT

BPK-29 disrupts the NR0B1 protein-protein interactions and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
CSRM617 is a Transcription Factor ONECUT2 Inhibitor for Prostate Cancer

CSRM617 is a selective inhibitor of ONECUT2 (OC2). CSRM617 induces apoptosis. Well tolerated in the prostate cancer mouse model.
PTC596 is an Orally Active and Selective BMI-1 Inhibitor

PTC596, an orally active and selective BMI-1 inhibitor, induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.
SS-208 is a Selective HDAC6 Inhibitor for Melanoma

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model.
AZD0424 is an Orally Active and Dual Selective Src/Abl Kinase Inhibitor

AZD0424 is a selective Src/Abl kinase inhibitor with potential antineoplastic activity. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells
BY27 is a Selective and Orally Active BET BD2 Inhibitor

BY27 is a potent, selective BET BD2 inhibitor, shows high BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. BY27 has anti-cancer activity.
KPT-6566 is a Selective PIN1 Inhibitor

KPT-6566 is a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1.
VU0155069, a Selective PLD1 Inhibitor, Blocks Tumor Cell Invasion

VU0155069 is a selective phospholipase D1 inhibitor with an IC50 of 46 nM, which strongly inhibits the invasive migration of several cancer cell lines.
MPT0E028, an Orally Active HDAC Inhibitor, Induces Apoptosis by Targeting HDAC and Akt

MPT0E028 is an orally active and selective histone deacetylase (HDAC) inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6.
DVD-445 is a TrxR1 Inhibitor for Cancer Therapy

DVD-445 is a potent peptidomimetic covalent TrxR1 inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Blogs (28)