Blogs | MedChemExpress

FTI-2153 is a Highly Selective Farnesyltransferase Inhibitor

FTI-2153 is a potent and highly selectiveof farnesyltransferase (FTase) inhibitor and a highly potent antagonist of oncogenic H-Ras signaling.
IPR-803 is a Potent Inhibitor of the uPAR•uPA Protein-Protein Interaction

IPR-803 is a potent inhibitor of the uPAR•uPA protein-protein interaction, and binds directly to uPAR with sub-micromolar affinity.
OTS964 is an Orally Active TOPK and CDK11 Inhibitor

OTS964 is an orally active, high affinity and selective TOPK inhibitor and is also a potent inhibitor of the cyclin-dependent kinase CDK11.
JTE-013 is a Specific S1P2 Antagonist in Neuroblastoma

JTE-013 is a potent and specific S1P2 antagonist and increases the excitability of sensory neurons independently of the receptor.
BI 167107 is a Highly Potent Agonist of the β2 Adrenergic Receptor

BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM.
Tasisulam, an Antitumor Agent, Inhibits Mitotic Progression and Induces Apoptosis

Tasisulam is an anticancer agent and induces apoptosis, which also inhibits mitotic progression and induces vascular normalization.
sAJM-589 is a Myc Inhibitor by Disrupts the Myc-Max Heterodimer

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer in a dose dependent manner with an IC50 of 1.8 μM.
CD161 is an Orally Active BET Bromodomain Inhibitor

CD161 is a potent and orally bioavailable bromodomain and extra-terminal bromodomain inhibitor with an IC50 of 28.2 nM and a Ki of 8.2 nM for BRD4 BD1.
NV03 is a Selective Antagonist for UHRF1-TTD Interaction with H3K9me3

NV03 is a potent and selective antagonist of UHRF1-H3K9me3 interaction by binding to UHRF1 TTD with a Kd of 2.4 μM and has anticancer activity.
CG-200745, a HDAC Inhibitor, Induces the Accumulation of p53

CG-200745 is a potent and pan HDAC inhibitor. CG200745 inhibits the deacetylation of histone H3 and tubulin, inducing p53 accumulation.

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Blogs (17)