Blogs | MedChemExpress

GNE-618 is a Orally Active NAMPT Inhibitor

GNE-618 is an orally active NAMPT inhibitor and reduces tumor growth. GNE-618 depletes NAD levels and induces tumor cell death.
S516 is a Potent Tubulin Polymerization Inhibitor

S516 is a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM and has marked antitumor activity against murine and human solid tumors.
AC-73 is a Specific and Orally Active CD147 Dimerization Inhibitor

AC-73 is a first specific, orally active the cluster of differentiation 147 (CD147) inhibitor and specifically disrupts CD147 dimerization.
DS18561882 is Selective and Orally Active MTHFD2 Inhibitor

DS18561882 is a highly potent, sozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with a good oral pharmacokinetic profile.
CP5V is a Specific PROTAC Degrader of Cdc20

CP5V is a PROTAC, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation.
AG-825, a selective ErbB2 inhibitor with anti-cancer effect

AG-825 is a selective and ATP-competitive ErbB2 inhibitor and leads to a decrease in ErbB2–nucleolin interaction, which suppresses tyrosine phosphorylation.
MRTX849 is an Orally Active and Covalent Inhibitor of KRAS G12C

MRTX849 is a potent, orally-available, and mutation-selective covalent inhibitor of KRASG12C with potential antineoplastic activity.
IACS-8803 is a Cyclic Dinucleotide STING Agonist

IACS-8803 is a highly potent cyclic dinucleotide stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy.
SU16f is a Selective PDGFRβ Inhibitor for Gastric Cancer Therapy

SU16f is a selective PDGFRβ inhibitor and significantly decreases the enhanced migratory ability of SGC-7901 cells by GC-MSC.
JNJ-10198409, an orally active PDGF-RTK inhibitor

JNJ-10198409 is an orally active PDGF-RTK inhibitor (IC50=2 nM). It also has potent activity against PDGFR-β (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM).

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Blogs (15)