Blogs | MedChemExpress

GSK778 is a Potent and Selective Inhibitor of BET BD1

GSK778 is a potent and selective inhibitor of bromodomain (BRD) BD1 and offers a super survival advantage in the aggressive MLL-AF9 AML model.
AMG-458 is a Selective and Orally Bioavailable c-Met Inhibitor

AMG-458 is a potent, selective and orally bioavailable c-Met inhibitor with potent anti-tumor activity in the NIH3T3/TPR-Met and U-87 MG xenograft models.
EW-7195 is a Specific ALK5 (TGFβR1) Inhibitor with Anti-Metastasis Activity

EW-7195 is a potent and selective ALK5 inhibitor, and efficiently inhibits TGF-β1-induced Smad signaling, EMT and breast tumour metastasis to the lung.
SR7826 is a Selective and Orally Active LIM kinase (LIMK) Inhibitor

SR7826 is a potent, selective and orally active LIM kinase (LIMK) inhibitor. SR7826 is highly efficient in inhibiting cell-invasion/migration in PC-3 cells.
TAI-1 is an Orally Active and Highly Potent Hec1 Inhibitor

TAI-1 is an orally active and highly potent first-in-class Hec1 (Ndc80) inhibitor and disrupts Hec1-Nek2 protein interaction, leads to Nek2 degradation.
MRK-740 is a Selective and PRDM9 Histone Methyltransferase Inhibitor

MRK-740 is a selective PRDM9 inhibitor. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets.
RA375, a RPN13 Inhibitor, Activates UPR Signaling, ROS Production and Apoptosis

RA375, a RPN13 inhibitor, inhibits proteasome function in muscle. RA375 is highly active against cell lines of multiple myeloma and diverse solid cancers.
TH1834 is a Specific Tip60 Histone Acetyltransferase (HAT) Inhibitor

TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer.
HJC0416 is a Highly Potent and Orally Active STAT3 Inhibitor

HJC0416 is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile. HJC0416 is a promising anti-cancer agent for breast cancer study.
S2116 is a Potent Lysine-Specific Demethylase 1 (LSD1) Inhibitor

S2116 is a potent lysine-specific demethylase 1 (LSD1) inhibitor and increases H3K9 methylation, reciprocal H3K27 deacetylation at super-enhancer regions.

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Blogs (18)