Blogs | MedChemExpress

VZ185 is a Selective Dual BRD7/9 PROTAC Degrader

VZ185 is a highly selective, potent, and rapid dual degrader with a slight preference for BRD9 over BRD7.
UNC6852 is a Selective Rolycomb Repressive Complex 2 (PRC2) PROTAC Degrader

UNC6852 is a chemical degrader that targets polycomb repressive complex 2 (PRC2). Anti-proliferative in diffuse large B cell lymphoma cell lines.
dFKBP-1 is a Potent and PROTAC-based FKBP12 Degrader

dFKBP-1 induces potent and dose-dependent degradation of FKBP12 in 293FT-WT cells. A facile and general new strategy to control target protein stability.
BI-3663 is a Highly Selective PTK2/FAK PROTAC

BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with cereblon ligands to hijack E3 ligases for PTK2 degradation.
GNE-987, a BET PROTAC Degrader, is a Part of PROTAC-Antibody (CLL1) Conjugate for ADC

GNE-987, a potent chimeric BET degrader, exhibits picomolar cell BRD4 degradation activity. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC).
SIAIS178 is a Potent and Selective PROTAC-Based BCR-ABL Degrader

SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology by recruiting VHL E3 ubiquitin ligase. SIAIS178 has anticancer activity.
BETd-260 is a Potent PROTAC BET Degrader

BETd-260 is a highly potent, efficacious, and promising BET degrader.
ZXH-3-26 is a Selective PROTAC BRD4 Degrader

ZXH-3-26 is a Selective PROTAC BRD4 Degrader and allows pharmacologic targeting of BRD4 without significant inhibition or degradation of BRD2/3.
dTRIM24 is a Selective PROTAC Degrader of TRIM24

dTRIM24 will be a useful tool to further probe the function of TRIM24 by rapid chemical depletion in hematopoietic cancers and other biological contexts.
DT2216 is a Selective PROTAC Degrader of BCL-XL

DT2216 is a potent and selective BCL-XL degrader based on PROTAC technology. DT2216 inhibits leukemia and has potent anti-cancer activity.

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Blogs (16)