Blogs | MedChemExpress

PND-1186 is a Highly-Specific FAK Inhibitor and Induces Apoptosis

PND-1186 is a FAK inhibitor and selectively promotes tumor cell apoptosis in three-dimensional environments. Acts as an anti-cancer therapy.
DMU-212 Possesses Antimitotic, Anti-Proliferative, Antioxidant and Apoptosis Promoting Activities

Activation of ERK1/2 is required for the antimitotic activity of the Resveratrol analogue DMU‐212 in human melanoma cells.
BI-3802-Induced Polymerization Triggers Degradation of BCL6

BI-3802, a BCL6 degrader, inhibits the BCL6 BTB domain. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1.
CTPI-2 is a Mitochondrial Citrate Carrier SLC25A1 Inhibitor

CTPI-2 is a SLC25A1 inhibitor. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. Antitumor activity.
EMI56 is a Superior Mutant EGFR Inhibitor

EMI56 is a Superior Mutant EGFR InhibitorLung Cancer, Non-Small Cell Lung Cancer A drug discovery platform to identify compounds that inhibit EGFR triple mutants.
SAR-020106 is an ATP-Competitive and Selective CHK1 Inhibitor

SAR-020106 is an ATP-competitive CHK1 inhibitor with an IC50 of 13.3 nM for hCHK1. SAR-020106 can enhance antitumor activity with selected anticancer drugs.
CHDI-390576 is a CNS Penetrant Class IIa HDAC Inhibitor

CHDI-390576, a potent and CNS penetrant class IIa HDAC inhibitor, show selectivity over class I HDACs, HDAC8 and the class IIb HDAC6 isoform.
ML132 is a Potent and Selective Caspase 1 Inhibitor

ML132, a potent and selective caspase 1 inhibitor with a unique selectivity pattern, is responsible for the proteolytic activation of IL-1β and IL-18.
BMS-P5 is an Orally Active PAD4 Inhibitor

BMS-P5 is an orally active PAD4 inhibitor. BMS-P5 blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model
VERU-111 is an Orally Bioavailable α and β Tubulin Inhibitor

VERU-111 inhibits the expression of tubulin βIII and βIV over other isotypes, which supports the ability of VERU-111 to surmount drug resistance.

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Blogs (16)