Blogs | MedChemExpress

BMS453 is a RARβ Agonist and a RARα/RARγ Antagonist

The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFβ and causing cell cycle arrest
BI99179 is a Selective Type I FASN Inhibitor

FASN is a key enzyme for lipogenesis and highly expressed in lipogenic tissues. BI99179 is a Selective Type I FASN Inhibitor.
NVS-CECR2-1 is a CECR2 BRD (non-BET Family) Inhibitor

NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective CECR2 inhibitor with potent anti-cancer activity.
ICCB280 is a Potent C/EBPα Inducer with Anti-Leukemic Properties

ICCB280, a inducer of C/EBPα, exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis.
JH-XI-10-02 is a Highly Potent and Selective PROTAC CDK8 Degrader

JH-XI-10-02, a highly Potent CDK8 Degrader, modulates the CDK8 protein levels. A viable therapeutic strategy in cancer.
NU6102 is a Potent CDK1 and CDK2 Inhibitor

NU6102 is a potent CDK1 and CDK2 inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively.
CMLD-2 is Inhibits HuR and Induces Apoptosis

CMLD-2, a HuR -ARE interaction inhibitor, competitively binds HuR protein and induces apoptosis. CMLD-2 has potent anti-cancer activity.
Senaparib is a Selective and Orally Active PARP1/2 Inhibitor

Senaparib, a selective and orally active PARP1/2 inhibitor, has great potential as a monotherapy as well as in combination with other agents.
Afatinib is an Irreversible and Orally Active EGFR Family Inhibitor

Afatinib is an irreversible EGFR family inhibitor and shows potent activity against wild-type and mutant forms of EGFR and HER2.
NSC-105808 is a Specific DNA2 Nuclease Inhibitor with Antitumor Activity

NSC-105808, a potent, specific DNA2 nuclease inhibitor, inhibits HR repair, DSB end resection and suppresses proliferation of cancer cells.

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Blogs (20)