Blogs | MedChemExpress

FLTX1, a Fluorescent Tamoxifen Derivative, Specifically Labels Intracellular Binding Sites (ER)

FLTX1 is a fluorescent Tamoxifen (Tx) derivative that specifically labels intracellular Tx-binding sites (estrogen receptors).
Elimusertib is an Orally Available and Selective ATR Inhibitor

Elimusertib is a potent, orally available and selective ATR inhibitor. Elimusertib has potent anti-tumor activity.
Olafertinib is a Third-Generation EGFR TKI

Olafertinib acts as a promising third-generation EGFR inhibitor. Olafertinib has the potential for NSCLC research.
UZH1a is a Selective METTL3 Inhibitor

UZH1a, a potent and selective METTL3 inhibitor can be used for epitranscriptomic modulation of cellular processes with antitumor activity.
DBPR112 is an Orally Active EGFR (both WT and Mutant) Inhibitor

DBPR112 is an orally active furanopyrimidine-based EGFR (WT and L858R/T790M) inhibitor with significant antitumor efficacy.
YUM70, a Selective GRP78 Inhibitor, Induces ER Stress-Induced Apoptosis

YUM70 inhibits GRP78. Induces endoplasmic reticulum stress-mediated apoptosis. Pancreatic cancer. Acts as a novel anticancer agent.
TPP-1 is a Potent Inhibitor of the PD-1/PD-L1 Interaction

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM).
Conglobatin, an Orally Active Hsp90 Inhibitor, Disrupts Hsp90-Cdc37 Complex Formation

Conglobatin inhibits proliferation and induces apoptosis by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation.
BIM-23190 is a Selective SSTR2 and SSTR5 Agonist

BIM-23190, a somatostatin analog, is a selective SSTR2 and SSTR5 agonist. BIM-23190 can be used in the study for cancer and acromegaly.
Z-LE(OMe)TD(OMe)-FMK is a Selective Caspase-8 Inhibitor

Z-LE(OMe)TD(OMe)-FMK is a Selective Caspase-8 Inhibitor. Caspase-8 is a cysteine protease for Fas-induced apoptosis and lymphocyte activation.

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Blogs (19)