Blogs | MedChemExpress

GSK2606414 is an Orally Available PERK Inhibitor

GSK2606414 is an orally available PERK inhibitor and is a potent compound of cancer and neurological diseases.
Birinapant (TL32711), a Bivalent Smac Mimetic, is an Antagonist for XIAP and cIAP1

Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 and induces apoptosis.
Wortmannin (SL-2052) is an Orally Active, Selective and Irreversible PI3K Inhibitor

Wortmannin is a potent, selective, irreversible and orally active PI3K inhibitor, with anticancer effects.
ARQ 531 (MK-1026) is a Reversible Non-Covalent and Orally Active BTK Inhibitor

ARQ 531 is a potent, ATP-competitive, reversible non-covalent and orally active BTK inhibitor, with anti-tumor activities.
Sorafenib (Bay 43-9006) is an Orally Active Raf Inhibitor

Sorafenib (Bay 43-9006) is an orally active Raf inhibitor and induces autophagy and apoptosis with anti-tumor activity.
Cabozantinib is a potent Multiple Receptor Tyrosine Kinases (RTKs) Inhibitor

Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor with good anticancer activity.
SN-38 (NK012) is an Active Metabolite of the Topoisomerase I Inhibitor Irinotecan

SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan and inhibits DNA and RNA synthesis.
Everolimus (RAD001), a Rapamycin Derivative, is a Selective and Orally Active mTOR1 Inhibitor

Everolimus (RAD001), a Rapamycin derivative, is a selective and orally active mTOR1 inhibitor with anticancer activities.
Ruxolitinib (INCB018424) is an Orally Active JAK1 and JAK2 Inhibitor

Ruxolitinib is a potent and selective JAK1/2 inhibitor and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy.
Iberdomide (CC-220) is an Orally Active Cereblon (CRBN) E3 Ligase Modulator (CELMoD)

Iberdomide (CC-220) is an orally active cereblon (CRBN) E3 ligase modulator (CELMoD) with antitumor and immunostimulatory activities。

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Blogs (11)