Blogs | MedChemExpress

CX-5461 is an Orally Active rRNA Synthesis Inhibitor

CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis with potent antitumor activity.
SB 258719 is a Selective 5-HT7 Receptor Antagonist

SB 258719 is a selective 5-HT7 receptor antagonist and can be used for the research of cancer and neurological disease.
Brusatol (NSC 172924) is a Nrf2 Inhibitor

Brusatol inhibits the Nrf2 signaling pathway by reducing the protein level of Nrf2, with anticancer activities.
Quizartinib (AC220) is an Orally Active and Highly Selective FLT3 Tyrosine Kinase Inhibitor

Quizartinib (AC220) is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor.
Saracatinib (AZD0530) is a potent Src Family Inhibitor

Saracatinib is a potent Src inhibitor (IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk) and has anti-invasive activities.
Cytochalasin B is a Mycotoxin binding to the Barbed end of Actin Filaments

Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers.
Atuveciclib is a Highly Selective and Orally Active PTEFb, CDK9 Inhibitor

Atuveciclib (BAY-1143572) is a highly selective, oral PTEFb/CDK9 inhibitor with potent antitumor activity.
Ganetespib (STA-9090) is a HSP90 Inhibitor

Ganetespib is a unique Hsp90 inhibitor that exhibits potent and sustained antitumor effects in a broad range of malignancies.
Elesclomol (STA-4783) is an Oxidative Stress Inducer and Induces Apoptosis

Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer.
Sapanisertib is an Orally Active and ATP-Dependent mTOR Inhibitor

Sapanisertib is an orally available, potent, and highly selective mTORC1/2 inhibitor demonstrating promise in numerous malignancies.

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Blogs (13)