Blogs | MedChemExpress

Troglitazone is an Orally Active PPARγ Agonist

Troglitazone is a potent PPARγ agonist with antitumor activies. Troglitazone has the potential for the research of the pancreatic cancer.
Fadrozole is a Potent, Selective and Nonsteroidal Aromatase Inhibitor

Fadrozole is a potent, selective, and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. Can be used for cancer research.
Axitinib is a Multi-Targeted Tyrosine Kinase Inhibitor

Axitinib is a multi-targeted tyrosine kinase inhibitor and potently inhibitor VEGFR1, VEGFR2, VEGFR3 and PDGFRβ.
PR-104A is a Hypoxia-Selective DNA Cross-Linking Agent and Cytotoxin

PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. Leukemia (T-ALL).
A 83-01 is a Potent Inhibitor of TGF-β Type I Receptor ALK5 Kinase

A 83-01 is an inhibitor of ALK5/4/7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5/4/7, respectively.
Cyclopamine is a Hedgehog (Hh) Pathway Antagonist

Cyclopamine is a potent Hedgehog (Hh) pathway antagonist and a selective Smo inhibitor with antitumor activity.
Oltipraz is a Nrf2 Inhibitor

Oltipraz is a potent Nrf2 activator. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, the IC50 is 10 μM.
Crizotinib is an Orally Active, ATP-Competitive ALK and c-Met inhibitor

Crizotinib is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Anti-tumor activity.
Anisomycin, a Protein Synthesis Inhibitor, also Interferes DNA Synthesis

Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis. Anisomycin is a JNK activator.
IMD-0354 is a Selective IKKβ Inhibitor

IMD-0354 is a selective IKKβ inhibitor and potently inhibits NF-κB activity. IMD0354 has antitumor activity.

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Blogs (13)