Blogs | MedChemExpress

Alda-1 is a potent ALDH2 Agonist

Alda-1 ameliorates H2O2-induced Achilles tendinopathy. Alda-1 could be used for preventing Achilles tendinopathy.
ABT-737 is a Selective and BH3 Mimetic Bcl-2, Bcl-xL and Bcl-w Inhibitor

ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor and has the potential for acute myeloid leukemia (AML) research.
Almonertinib is an Orally Active and Irreversible EGFR Inhibitor

Almonertinib is an orally available, third-generation EGFR TKI with selectivity for EGFR-sensitizing and T790M resistance mutations.
Apitolisib is an Orally Active Class I PI3K and mTORC1/2 Inhibitor

Apitolisib is a potent Class I PI3 kinase and mTORC1/2 inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/β/δ/γ, respectively.
MS4322 is a First-in-Class PRMT5 PROTAC Degrader

MS4322 is a first-in-class PRMT5 degrader and a valuable chemical tool for exploring the PRMT5 functions in vitro and in vivo.
Zebularine is a DNA Methyltransferase Inhibitor

Zebularine is a potent DNA methyltransferase inhibitor with anti-tumor activity. Zebularine also inhibits cytidine deaminase.
MRTX1133 is a Highly Selective, First-in-Class Inhibitor of KRAS G12D

MRTX1133, a selective, first-in-class inhibitor of KRAS G12D, selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells.
AZD1390 is a Highly Selective, Orally Active and Brain-Penetrant ATM Inhibitor

AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM.
CBL0137 is an Histone Chaperone FACT Inhibitor

CBL0137 is an inhibitor of the histone chaperone, FACT. CBL0137 activates p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 µM, respectively.
Trolox, an Analogue of Vitamin E, Possesses Antioxidant Effect

Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage.

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Blogs (13)