Blogs | MedChemExpress

Xentuzumab is a Monoclonal Antibody That Targets IGF Ligands IGF1 and IGF2

Xentuzumab is an anti-IGF-1/2 mAb, also targets to INSR-A. Xentuzumab inhibits tumor proliferation and induces apoptosis.
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP

TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 inhibits NF-κB pathway and epithelial-mesenchymal transition (EMT).
MMRi62, a Ferroptosis Inducer Targeting MDM2-MDM4

MMRi62, a Ferroptosis inducer targeting MDM2-MDM4. MMRi62 shows a P53-independent pro-apoptotic activity against PDAC cells.
D6808 is a Highly Selective c‑Met Inhibitor used for NSCLC and Gastric Cancer Research

D6808 is a highly selective and potent c‑Met inhibitor. D6808 can be used for the research of NSCLC and gastric cancers
SJ988497, a PROTAC JAK2 Degrader, used for Acute Lymphoblastic Leukemia Research

SJ988497 is a cell permeable PROTAC JAK2 degrader that degrades JAK2 in vitro and in vivo, and shows anticancer activity against leukemia.
Manzamine A, an Orally Active β-Carboline Alkaloid with Antiviru, Antimalarial and Anticancer Activities

AManzamine A is an orally active β-carboline alkaloid effective against HSV-1, Cancer, and Malaria.
Ganitumab (AMG 479) is an IGF1R mAb for Cancer Research

Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human IGF1R. Ganitumab can be used in research of cancer.
Rohinitib is a Specific eIF4A Inhibitor Used for Acute Lymphoblastic Leukemia Research

Rohinitib is a potent and specific eIF4A inhibitor that induce apoptosis of AML cell lines and shows anti-AML effects in vivo.
CYD-4-61 is a Bax Activator Used for Breast Cancer Research

CYD-4-61 is a novel Bax activator. It induces cytochrome c release, mitochondrial membrane penetration, consequently leads to cell apoptosis.
NecroIr2 is an Iridium(III) Complex, Can be Used as an Anticancer Agent

NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R).

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Blogs (21)