1. Metabolic Enzyme/Protease Anti-infection
  2. TMV Phosphatase Lipoxygenase
  3. Lobaric acid

Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).

For research use only. We do not sell to patients.

Lobaric acid Chemical Structure

Lobaric acid Chemical Structure

CAS No. : 522-53-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All Lipoxygenase Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).

Cellular Effect
Cell Line Type Value Description References
BXPC-3 EC50
1.6 μM
Compound: 4
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
HCT-116 EC50
0.8 μM
Compound: 4
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
HT-29 EC50
2.39 μM
Compound: Lobaric acid
Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
[PMID: 24900447]
HT-29 IC50
4.54 μM
Compound: Lobaric acid
Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
[PMID: 24900447]
J82 EC50
3.6 μM
Compound: 4
Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
K562 EC50
1.4 μM
Compound: 4
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
U2OS EC50
17.6 μM
Compound: Lobaric acid
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
[PMID: 24900447]
UMUC3 EC50
3.7 μM
Compound: 4
Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
Molecular Weight

456.49

Formula

C25H28O8

CAS No.
SMILES

O=C(C1=C(O)C=C(C(OC2=CC(OC)=CC(C(CCCC)=O)=C23)=C1CCCCC)OC3=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Lobaric acid
Cat. No.:
HY-117085
Quantity:
MCE Japan Authorized Agent: