LOE 908 hydrochloride

Cat. No.: HY-107756: FAQs
Data Sheet Handling Instructions

Molarity Calculator

LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor.

For research use only. We do not sell to patients.

LOE 908 hydrochloride Chemical Structure

CAS No. : 143482-60-4

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of LOE 908 hydrochloride:

Pinokalant Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Calcium Channel Isoform Specific Products:

View All Isoforms

N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	12.6 μM Compound: LOE 908 Hydrochloride	Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]
HepG2	EC₅₀	3.2 μM Compound: LOE 908 Hydrochloride	Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]

In Vitro

LOE 908 hydrochloride blocks cation conductance in a concentration-dependent manner with an IC₅₀ of 560 nM, and blocks dihydropyridine-sensitive Ba²⁺ current through voltage-dependent Ca²⁺ channels with an IC₅₀ of 28 μM in voltage-clamped A7r5 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride attenuates acute neuromotor dysfunction in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Sprague-Dawley rats, lateral fluid percussion brain injury model^[2]
Dosage:	4 mg/kg bolus followed by 160 mg/kg over 24 h or 2 mg/kg bolus followed by 80 mg/kg over 24 h
Administration:	Intravenous administration
Result:	Significantly improved neuromotor function at 48 h postinjury when compared to vehicle treatment.

Molecular Weight

749.29

Formula

C₄₁H₄₉ClN₂O₉

CAS No.

143482-60-4

SMILES

COC(C(OC)=C(OC)C=C1)=C1CCN(CCC2=C(C(OC)=C(OC)C=C2)OC)C(C(C3=CC=CC=C3)C4=NCCC5=CC(OC)=C(OC)C=C45)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Krautwurst D, et al. The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 1994 Mar;349(3):301-7. [Content Brief]

[2]. Cheney JA, et al. The novel compound LOE 908 attenuates acute neuromotor dysfunction but not cognitive impairment or cortical tissue loss following traumatic brain injury in rats. J Neurotrauma. 2000 Jan;17(1):83-91. [Content Brief]