Loliolid

Cat. No.: HY-118020A Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

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Loliolide, a Carotenoid Metabolite, is a potential endogenous inducer of herbivore resistance. Loliolide also inhibits the seedling growth.

For research use only. We do not sell to patients.

Loliolid Chemical Structure

CAS No. : 5989-02-6

Size	Price	Stock	Quantity
1 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Loliolide, a Carotenoid Metabolite, is a potential endogenous inducer of herbivore resistance. Loliolide also inhibits the seedling growth.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 10 μM Compound: 19	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
HT-29	IC₅₀	> 10 μM Compound: S11	Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay	[PMID: 30057155]
HT-29	IC₅₀	> 10 μM Compound: S11	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
KB	IC₅₀	> 10 μM Compound: 19	Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MCF7	IC₅₀	> 10 μM Compound: 19	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MDA-MB-231	IC₅₀	> 10 μM Compound: 19	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MDA-MB-231	IC₅₀	> 10 μM Compound: S11	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
MDA-MB-435	IC₅₀	> 10 μM Compound: S11	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
OVCAR-3	IC₅₀	> 10 μM Compound: S11	Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
RAW264.7	IC₅₀	> 0.4 μM Compound: loliolide	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs	[PMID: 20192236]
RAW264.7	CC₅₀	> 100 μM Compound: 11	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 33667099]
RAW264.7	IC₅₀	> 50 μM Compound: 11	Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA	[PMID: 24963714]
RAW264.7	IC₅₀	> 50 μM Compound: 11	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay	[PMID: 24963714]
RAW264.7	IC₅₀	56.7 μM Compound: 11	Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay	[PMID: 33667099]

Molecular Weight

196.24

Formula

C₁₁H₁₆O₃

CAS No.

5989-02-6

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12C(C(C)(C[C@@H](C1)O)C)=CC(O2)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

Methanol : 58.87 mg/mL (299.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0958 mL	25.4790 mL	50.9580 mL
5 mM	1.0192 mL	5.0958 mL	10.1916 mL
10 mM	0.5096 mL	2.5479 mL	5.0958 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (249 KB) HNMR (220 KB) LCMS (77 KB)

Handling Instructions (2659 KB)

References

[1]. Murata M, Nakai Y, Kawazu K, et al. Loliolide, a Carotenoid Metabolite, Is a Potential Endogenous Inducer of Herbivore Resistance. Plant Physiol. 2019;179(4):1822-1833. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol	1 mM	5.0958 mL	25.4790 mL	50.9580 mL	127.3950 mL
	5 mM	1.0192 mL	5.0958 mL	10.1916 mL	25.4790 mL
	10 mM	0.5096 mL	2.5479 mL	5.0958 mL	12.7395 mL
	15 mM	0.3397 mL	1.6986 mL	3.3972 mL	8.4930 mL
	20 mM	0.2548 mL	1.2740 mL	2.5479 mL	6.3698 mL
	25 mM	0.2038 mL	1.0192 mL	2.0383 mL	5.0958 mL
	30 mM	0.1699 mL	0.8493 mL	1.6986 mL	4.2465 mL
	40 mM	0.1274 mL	0.6370 mL	1.2740 mL	3.1849 mL
	50 mM	0.1019 mL	0.5096 mL	1.0192 mL	2.5479 mL
	60 mM	0.0849 mL	0.4247 mL	0.8493 mL	2.1233 mL
	80 mM	0.0637 mL	0.3185 mL	0.6370 mL	1.5924 mL
	100 mM	0.0510 mL	0.2548 mL	0.5096 mL	1.2740 mL

Loliolid Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Loliolid5989-02-6OthersInhibitorinhibitorinhibit

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Loliolid

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Complete Stock Solution Preparation Table

Loliolid Related Classifications

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