Lomifylline

Cat. No.: HY-114531 Purity: 99.67%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lomifylline is a derivative of Xanthine (HY-W017389). Lomifylline can be used in research of sepsis and septic or endotoxic shock, when combined with an antibody to TNF or a TNF binding fragment.

For research use only. We do not sell to patients.

Lomifylline Chemical Structure

CAS No. : 10226-54-7

Size	Price	Stock	Quantity
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

Lomifylline is a derivative of Xanthine (HY-W017389). Lomifylline can be used in research of sepsis and septic or endotoxic shock, when combined with an antibody to TNF or a TNF binding fragment^[1].

Molecular Weight

278.31

Formula

C₁₃H₁₈N₄O₃

CAS No.

10226-54-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=C(C2=O)N(C=N1)CCCCC(C)=O)C)N2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (359.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5931 mL	17.9656 mL	35.9312 mL
5 mM	0.7186 mL	3.5931 mL	7.1862 mL
10 mM	0.3593 mL	1.7966 mL	3.5931 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.67%

Select Batch:

Data Sheet (268 KB) SDS (392 KB)

COA (248 KB) HNMR (241 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Anagnostopulos H, et al., The use of antibodies to tnf or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor. WO9207585.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5931 mL	17.9656 mL	35.9312 mL	89.8279 mL
	5 mM	0.7186 mL	3.5931 mL	7.1862 mL	17.9656 mL
	10 mM	0.3593 mL	1.7966 mL	3.5931 mL	8.9828 mL
	15 mM	0.2395 mL	1.1977 mL	2.3954 mL	5.9885 mL
	20 mM	0.1797 mL	0.8983 mL	1.7966 mL	4.4914 mL
	25 mM	0.1437 mL	0.7186 mL	1.4372 mL	3.5931 mL
	30 mM	0.1198 mL	0.5989 mL	1.1977 mL	2.9943 mL
	40 mM	0.0898 mL	0.4491 mL	0.8983 mL	2.2457 mL
	50 mM	0.0719 mL	0.3593 mL	0.7186 mL	1.7966 mL
	60 mM	0.0599 mL	0.2994 mL	0.5989 mL	1.4971 mL
	80 mM	0.0449 mL	0.2246 mL	0.4491 mL	1.1228 mL
	100 mM	0.0359 mL	0.1797 mL	0.3593 mL	0.8983 mL

Lomifylline Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lomifylline10226-54-7OthersInhibitorinhibitorinhibit

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