2. Apoptosis
  3. Bcl-2 Family
  4. Lonitoclax

Lonitoclax is a B-cell lymphoma 2 (Bcl-2) inhibitor. Lonitoclax has comparable anti-tumor efficacy to Venetoclax (HY-15531) in both B cell and myeloid malignancy models. Lonitoclax is promising for research of relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas.

For research use only. We do not sell to patients.

Lonitoclax Chemical Structure

Lonitoclax Chemical Structure

CAS No. : 2952589-57-8

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Lonitoclax Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

Lonitoclax is a B-cell lymphoma 2 (Bcl-2) inhibitor. Lonitoclax has comparable anti-tumor efficacy to Venetoclax (HY-15531) in both B cell and myeloid malignancy models. Lonitoclax is promising for research of relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas[1].

Molecular Weight

733.29

Formula

C43H45ClN4O5
CAS No.
SMILES

O=C(N1[C@@H](CC2=CC=CC=C2C1)CN3CCOCC3)C4=C(C5=CC(C(N(C6=CC=C(C=C6)O)CC7=C(C(OC)=CC=C7)C)=O)=C(N5C)C)C=C(C=C4)Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lonitoclax Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lonitoclax2952589-57-8Bcl-2 FamilyBcl-2anti-tumor efficacyB cell and myeloid malignancy modelsInhibitorinhibitorinhibit

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