2. Autophagy
  3. LRRK2
  4. LRRK2-IN-10

LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research.

For research use only. We do not sell to patients.

LRRK2-IN-10 Chemical Structure

LRRK2-IN-10 Chemical Structure

CAS No. : 2704562-80-9

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LRRK2-IN-10 Related Antibodies

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Description

LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research[1].

Molecular Weight

341.37

Formula

C20H15N5O
CAS No.
SMILES

N#CC1=CC(CC2)=C(C=C1)[C@H]2NC3=CC4=C(C=C3)NN=C4C5=CON=C5
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Purity & Documentation
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LRRK2-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LRRK2-IN-102704562-80-9LRRK2Leucine-rich repeat kinase 2mutation-selectivebrain penetrantG2019S-LRRK2pS935pS1292Parkinson's diseaseInhibitorinhibitorinhibit

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