2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Histone Demethylase Apoptosis
  4. LSD1/HDAC-IN-2

LSD1/HDAC-IN-2 (Compound 20c) is the inhibitor for LSD and HDAC, that inhibits LSD1, HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with IC50s of 39.0, 1.4, 1.0, 1.3, 2.9 and 16.0 nM, respectively. LSD1/HDAC-IN-2 inhibits the proliferation of cancer cells, especially the colorectal cancer cells. LSD1/HDAC-IN-2 arrests the cell cycle at G2/M phase, inhibits cell migration, and induces apoptosis in HCT-116 and HT-29 cells. LSD1/HDAC-IN-2 exhibits antitumor efficacy in mouse model without significant toxicity.

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LSD1/HDAC-IN-2 Chemical Structure

LSD1/HDAC-IN-2 Chemical Structure

CAS No. : 2966782-82-9

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LSD1/HDAC-IN-2 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

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Description

LSD1/HDAC-IN-2 (Compound 20c) is the inhibitor for LSD and HDAC, that inhibits LSD1, HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with IC50s of 39.0, 1.4, 1.0, 1.3, 2.9 and 16.0 nM, respectively. LSD1/HDAC-IN-2 inhibits the proliferation of cancer cells, especially the colorectal cancer cells. LSD1/HDAC-IN-2 arrests the cell cycle at G2/M phase, inhibits cell migration, and induces apoptosis in HCT-116 and HT-29 cells. LSD1/HDAC-IN-2 exhibits antitumor efficacy in mouse model without significant toxicity[1].

IC50 & Target

HDAC2

1.0 nM (IC50)

HDAC3

1.3 nM (IC50)

HDAC1

1.4 nM (IC50)

HDAC6

2.9 nM (IC50)

HDAC8

16.0 nM (IC50)

KDM1/LSD1

39.0 nM (IC50)

Molecular Weight

390.48

Formula

C23H26N4O2
CAS No.
SMILES

NC1=C(C)C(C2=CN(CCCCCCC(NO)=O)C3=C2C=C(C#N)C=C3)=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1/HDAC-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1/HDAC-IN-22966782-82-9HDACHistone DemethylaseApoptosisHistone deacetylasesHCT-116HT-29BALB/c mouseA549LOVOMDA-MB-231EC-1DLD-1SW620M?V4-11THP-1colorectal cancerInhibitorinhibitorinhibit

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