LSTc (Synonyms: LS-tetrasaccharide c)

Cat. No.: HY-N10633 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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LSTc (LS-tetrasaccharide c) is a human lactooligosaccharide presents on glycoproteins and glycolipids. LSTc is also a specific human JC polyomavirus (JCV) recognition motif. LSTc has good potential for the study of progressive multifocal leukoencephalopathy (PML).

For research use only. We do not sell to patients.

LSTc Chemical Structure

CAS No. : 64003-55-0

Size	Price	Stock	Quantity
500 μg	USD 220	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Description

In Vitro

LSTc specifically engaged by JCV and inhibits JCV infection in SVG-A cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SVG-A cells
Concentration:	5 mM (pretreat LSTc with JCV, then JCV-LST complexes are added to cells)
Incubation Time:	1 h
Result:	Inhibited JCV infection.

Molecular Weight

998.88

Formula

C₃₇H₆₂N₂O₂₉

CAS No.

64003-55-0

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O[C@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)[C@H]1O[C@@H]([C@@H]([C@H]([C@H]3O)O)O)O[C@@H]3CO[C@]4(O[C@@]([C@@H]([C@H](C4)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (125.14 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0011 mL	5.0056 mL	10.0112 mL
5 mM	0.2002 mL	1.0011 mL	2.0022 mL
10 mM	0.1001 mL	0.5006 mL	1.0011 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (281 KB) SDS (251 KB)

COA (267 KB) HNMR (153 KB)

Handling Instructions (2659 KB)

References

[1]. Neu U, et al. Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif. Cell Host Microbe. 2010 Oct 21;8(4):309-19. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0011 mL	5.0056 mL	10.0112 mL	25.0280 mL
	5 mM	0.2002 mL	1.0011 mL	2.0022 mL	5.0056 mL
	10 mM	0.1001 mL	0.5006 mL	1.0011 mL	2.5028 mL
	15 mM	0.0667 mL	0.3337 mL	0.6674 mL	1.6685 mL
	20 mM	0.0501 mL	0.2503 mL	0.5006 mL	1.2514 mL
	25 mM	0.0400 mL	0.2002 mL	0.4004 mL	1.0011 mL
	30 mM	0.0334 mL	0.1669 mL	0.3337 mL	0.8343 mL
	40 mM	0.0250 mL	0.1251 mL	0.2503 mL	0.6257 mL
	50 mM	0.0200 mL	0.1001 mL	0.2002 mL	0.5006 mL
	60 mM	0.0167 mL	0.0834 mL	0.1669 mL	0.4171 mL
	80 mM	0.0125 mL	0.0626 mL	0.1251 mL	0.3129 mL
	100 mM	0.0100 mL	0.0501 mL	0.1001 mL	0.2503 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

LSTc Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSTc64003-55-0LS-tetrasaccharide cOthersPMLJCVvirushuman lactooligosaccharideSVG-A cellsInhibitorinhibitorinhibit

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