Lucanthone hydrochloride 

Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

APE-1^[1]

Lucanthone hydrochloride is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone hydrochloride, cell viability is measured by MTT assay. Lucanthone hydrochloride reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone hydrochloride is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC₅₀ of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

376.94

C₂₀H₂₅ClN₂OS

548-57-2

O=C1C2=C(C(C)=CC=C2NCCN(CC)CC)SC3=C1C=CC=C3.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18.  [Content Brief]

  [2]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.  [Content Brief]