2. Apoptosis
  3. c-Myc
  4. Lusianthridin

Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.

For research use only. We do not sell to patients.

Lusianthridin Chemical Structure

Lusianthridin Chemical Structure

CAS No. : 87530-30-1

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Based on 1 publication(s) in Google Scholar

Lusianthridin Related Antibodies

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Description

Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 11
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
HeLa IC50
> 10 μM
Compound: 11
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
HSC-T6 IC50
61.2 μM
Compound: 17
Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
[PMID: 18052323]
MCF7 IC50
> 10 μM
Compound: 11
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
RAW264.7 IC50
4.6 μM
Compound: Lusianthridin
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
[PMID: 29280630]
In Vitro

Lusianthridin (0-100 μM) inhibits cell viability at concentrations greater than 50 μM in both H460 and H292 cells[1].
Lusianthridin significantly reduces the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentration 5, 10, and 20 μM Lusianthridin, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lusianthridin Related Antibodies

Cell Viability Assay[1]

Cell Line: The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells[1]. 0-100 μM.
Concentration: 0-100 μM.
Incubation Time: 24 h.
Result: Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.
Molecular Weight

242.27

Formula

C15H14O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C=C1CC2)=CC=C1C3=C2C=C(OC)C=C3O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References
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Lusianthridin Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lusianthridin87530-30-1c-MycMycInhibitorinhibitorinhibit

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